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Radiation-Induced Coronary Artery Disease in Lung and Breast Cancer Patients

Year: 2025
Type: review
Abstract: Radiation-induced coronary artery disease (RI-CAD) is a significant cardiovascular complication for cancer survivors treated with thoracic radiation therapy (RT). Despite advances in RT techniques, exposure to the heart during treatment remains a critical factor influencing long-term cardiac outcomes, particularly in patients with breast and lung cancer. RI-CAD develops due to radiation-induced endothelial injury, inflammation, and accelerated atherosclerosis, presenting a unique and aggressive disease profile. This review explores the pathophysiology, risk factors, and diagnostic advancements for RI-CAD, emphasizing the role of PET in improving patient outcomes.
Source: PET Clinics
DOI: 10.1016/j.cpet.2025.01.006
Authors: Dev Patel, Chitra Parikh, Daniel Gharavi, Shiv Patil, Thomas Werner, Charles B. Simone, Abass Alavi
Institutions: Hospital of the University of Pennsylvania, University of Pennsylvania, Virginia Commonwealth University, Thomas Jefferson University, Memorial Sloan Kettering Cancer Center, New York Proton Center
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,400
OpenAlex ID: W4407582895
FWCI: 0.545
Cites: 51
Cited by: 3
Related to: 10