Spontaneous Self‐Organized Order Emerging From Intrinsically Disordered Protein Polymers
Year: 2025
Type: article
Abstract: Intrinsically disordered proteins (IDPs) are proteins that, despite lacking a defined 3D structure, are capable of adopting dynamic conformations. This structural adaptability allows them to play not only essential roles in crucial cellular processes, such as subcellular organization or transcriptional control, but also in coordinating the assembly of macromolecules during different stages of development. Thus, in order to artificially replicate the complex processes of morphogenesis and their dynamics, it is crucial to have materials that recapitulate the structural plasticity of IDPs. In this regard, intrinsically disordered protein polymers (IDPPs) emerge as promising materials for engineering synthetic condensates and creating hierarchically self-assembled materials. IDPPs exhibit remarkable properties for their use in biofabrication, such as functional versatility, tunable sequence order-disorder, and the ability to undergo liquid-liquid phase separation (LLPS). Recent research has focused on harnessing the intrinsic disorder of IDPPs to design complex protein architectures with tailored properties. Taking advantage of their stimuli-responsiveness and degree of disorder, researchers have developed innovative strategies to control the self-assembly of IDPPs, resulting in the creation of hierarchically organized structures and intricate morphologies. In this review, we aim to provide an overview of the latest advances in the design and application of IDPP-based materials, shedding light on the fundamental principles that control their supramolecular assembly, and discussing their application in the biomedical and nanobiotechnological fields.
DOI: 10.1002/wnan.70003
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,730
Funders: Banco Santander, Ministerio de Ciencia, Innovación y Universidades, European Commission, Ministerio de Ciencia e Innovación, Consejería de Educación, Junta de Castilla y León, Junta de Castilla y León, Centro en Red de Medicina Regenerativa y Terapia celular de Castilla y León, Horizon 2020 Framework Programme, European Regional Development Fund, Agencia Estatal de Investigación, European Social Fund
Awards: G1105844351, Training the new generation of industrial doctorates in the transition towards bio-based value circles, G1175115578, G121809054, G1363958350, G1508135929, G1519758885, G1622782223, "A novel multi-functional elastin-like recombinant hydrogel for the prevention of scar tissue formation following a myocardial infarction: ""ELR-SCAR""", G1855990336, G2001806450, G210041235, G2161408835, G2262748287, G2263589966, G2309174360, G2601397997, G2628364946, G2660406951, G279363373, G300979063, G305621269, G3306623903, G3345895242, G34346518, G3480869486, G3518538256, G3681454997, G3844497849, G3993834804, G4012842235, G4042783231, G410571670, G425668148, G430777504, G4442677895, G451917667, G4526231891, G4724655521, G4820502543, G491712853, G4937468798, G502190717, G5080475149, G5195188938, G5404395142, G5421974903, G546199279, G5539308778, G5635532810, G5967599077, G5987792135, G5998035708, G6218905885, G624877701, G6529851592, G683931746, G7084143925, G7169023097, G7330179772, G7434936867, G751615522, G7666367276, G7805626310, G7863371703, G7984235579, G8157993089, G841636556, G8497050386, G8512683158, G8888022036, G8920660035, G897484643, G929308097, G99296377
OpenAlex ID: W4407585761