MLH1 and MSH2 expression in endometrial cancer - microscopic and computer assessment of immunohistochemical method.
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: We aimed to compare MLH1 and MSH2 protein expression and Mismatch repair (MMR) status with clinical data: diagnosis, grading, and staging. Moreover, we wanted to assess any correlation between two immunohistochemical assessments: classic microscopic and computer analysis performed by a calibrated program. MATERIALS AND METHODS: in five fields of vision. RESULTS: <0.001). CONCLUSION: We did not find a relationship between MMR status and grading, staging, or diagnosis. However, we present a novel approach to immunohistochemical assessment using computer analysis. It allows us to carry out more objective and accurate studies with the IHC method.
Source: PubMed
DOI: 10.14670/hh-18-884
Institution: Poznan University of Medical Sciences
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4407592933