Year: 2025
Type: article
Abstract: Objective In the kidney, the medulla is most susceptible to damage in case of hampered perfusion or oxygenation. Due to separate regulation of cortical and medullary perfusion, measurement of both is crucial to improve the understanding of renal pathophysiology. We aim to develop and evaluate a physiologically accurate model to measure renal inner medullary (Fmed) and cortical perfusion (Fcor) separately. Materials and methods We developed a 7-compartment model of renal perfusion and used an iterated approach to fit 10 free parameters. Model stability and accuracy were tested on both patient data and simulations. Cortical perfusion and FT (tubular flow or glomerular filtration rate per unit of tissue volume) were compared to a conventional 2-compartment filtration model. Results Average (standard deviation) Fmed was 37(23)mL/100 mL/min. Fitting stability as expressed by the median (interquartile range) coefficient of variation between fits was 0.0(0.0–5.8)%, with outliers up to 81%. In simulations, Fmed was underestimated by around 8%. Intra-class correlation coefficients for Fcor and FT as measured with the 2- and 7- compartment model were 0.87 and 0.63, respectively. Discussion We developed a pharmacokinetic model closely following renal physiology. Although the results were vulnerable for overfitting, relatively stable results could be obtained even for Fmed.
Authors: A. de Boer, K. Sharma, B. Alhummiany, S. P. Sourbron
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,090
Funders: Stichting de Drie Lichten, Horizon 2020
Award: G3834860354
OpenAlex ID: W4407593207