Year: 2025
Type: article
Study design: Case Report
Abstract: Introduction Nephrotic syndrome (NS) is characterized by the presence of proteinuria of ≥ 3 g/24 h, hypoalbuminemia < 2.5 g/dl, peripheral edema, and severe hyperlipidaemia. NS is associated with increased risk of deep venous thrombosis (DVT), and, consequently, pulmonary embolism (PE) . Case presentation We report a case of a severe PE in a young patient with NS, admitted to the Emergency Medicine Department of the University Hospital Sant’Andrea of Rome. Conclusions The aim of this report is to allow a more comprehensive knowledge of the SN and its related EP highlighting both the risk of underdiagnosis and the need of a multidisciplinary approach by a team of different specialists. We also reviewed pathophysiology of hypercoagulability in NS characterized by the imbalance of prothrombotic and antithrombotic factors, and by impaired thrombolytic activities. A more complete knowledge of the clinical and laboratory features of NS and its related PE appears to be crucial for the early diagnosis and treatment.
Authors: A. Dulcetti, C. Bruscia, D. M. Malena, G. Murante, A. Angelino, M. Rocchietti March, B. Mariani, B. Alfei, A. Martocchia, G. Sesti
Institutions: Azienda Ospedaliera Sant'Andrea, Sapienza University of Rome
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,090
Funder: Sapienza Università di Roma
OpenAlex ID: W4407593577