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Ameliorative Effect of Tribulus Terrestris on Liver Biochemical Parameters in Albino Rat After Treatment With Drug Flutamide

Year: 2023

Type: article

Abstract: Chemicals that lessen the harmful effects of hepatotoxic substances on the liver are known as hepatoprotective agents.While some researchers thought of strengthening, tonic, and fortifying. Tribulus terrestris, a leafy herb used in folk medicine, has shown hepatoprotective effects in several studies. The experiment involved the administration of drug toinduce liver damage, followed by treatment with Tribulus terrestris extract. Hepato-biochemical parameters, including serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were monitored to assess liver function and damage. Results showed a significant elevation in ALT, AST and ALP levels in rats treated with flutamide. However, co-administration of Tribulus terrestris extract resulted in a marked reduction in these biochemical parameters, suggesting a protective effect on liver function. The study clearly states that Tribulus terrestris extract exhibits hepatoprotective and effect, mitigating the hepatotoxicity induced by flutamide. These findings suggest that Tribulus terrestris could be considered as a supplementary agent to protect against drug-induced liver damage during long term treatments.

Source: Journal of Science Innovations and Nature of Earth

DOI: 10.59436/trpq5296

Authors: Ajay Pratap Singh, P.K. Singh, Harendra Nath Sharma

Institution: Dr. Bhimrao Ambedkar University

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4407595035

FWCI:

Cites: 4

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Related to: 10