Work

Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer’s mouse model

Year: 2025

Type: article

Abstract: = 58, males). Starting in early adulthood (p60), mice underwent 12-h daily rocking during the light period for four months. Rocking increased non-rapid eye movement (NREM) sleep initially, although habituation reduced this effect over time. Despite habituation, rocking slowed motor decline and reduced beta-amyloid levels in the cerebral cortex and hippocampus. However, tau levels remained unaffected. In conclusion, our findings highlight the potential of non-pharmacological methods to enhance NREM sleep and modify disease trajectory in AD models.

Source: iScience

DOI: 10.1016/j.isci.2025.112036