Work

Trichosporon asahii and Candida guilliermondii as a Source of Orbital Infection in an Immunocompromised Individual

Year: 2025

Type: article

Abstract: A 47-year-old male with a history of immunosuppression and recent intensive care unit admission presented with progressive orbital swelling and pain. Blood cultures grew Trichosporon asahii and Candida guilliermondii, with matching positive cultures from peripheral and central venous samples. Given his fungemia and worsening orbital involvement, induction therapy with amphotericin B and isavuconazole was initiated. Within weeks, clinical improvement was noted, prompting a transition to long-term consolidation therapy with oral posaconazole and isavuconazole. At follow-up, the patient demonstrated sustained clinical stability with no recurrence of infection. Orbital involvement from fungemia due to T. asahii and C. guilliermondii is rare, and management requires early recognition, aggressive antifungal therapy, and careful monitoring.

Source: Cureus

DOI: 10.7759/cureus.79062

Authors: David Morcos, Kevin Hardy, Anthony Makovec, Morgan Schill, John Foxworth

Institutions: University of Missouri–Kansas City, Louisiana State University Health Sciences Center New Orleans, Truman Medical Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407598001