Work

Disseminated histoplasmosis presenting as adrenal insufficiency: A case report

Year: 2025

Type: article

Abstract: This report aims to highlight rarity of disseminated histoplasmosis (DH) presenting as adrenal insufficiency and the need for considering it in the differential diagnosis, even in non-endemic areas. A case is presented of a 69-year-old male patient with a background of hypertension and diabetes mellitus, with a persistent fever, significant loss of weight, and general weakness. Imaging studies showed adrenal masses in both adrenal glands, and laboratory tests showed hyperkalemia and hyponatremia. Hormonal tests confirmed the diagnosis of adrenal insufficiency. CT-guided adrenal biopsy confirmed the diagnosis of histoplasmosis. The patient received a 14-day course of Amphotericin B, followed by oral Itraconazole and glucocorticoid substitution therapy, with improvement in adrenal function over a period of time.

Source: Medical Mycology Case Reports

DOI: 10.1016/j.mmcr.2025.100698

Authors: Md. Asaduzzaman, Ranjon Kumer Roy, Suchanda Roy, Nasad Ahmed, Sazeda Akter, Monotush Ronjon Chando

Institutions: Sylhet MAG Osmani Medical College, Sylhet MAG Osmani Medical College Hospital, Jalalabad Ragib Rabeya Medical College

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650