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The Pancreatitis Puzzle: Antimelanoma Differentiation-Associated Gene-5 Dermatomyositis Unveiled

Year: 2025

Type: article

Abstract: Antimelanoma differentiation-associated gene (MDA)-5 dermatomyositis, a subtype of inflammatory myopathy, is associated with interstitial lung disease and distinctive skin findings. We report a 39-year-old woman presenting with pancreatitis as the first presentation of anti-MDA-5 dermatomyositis. The patient had no pancreatitis risk factors, and her muscle enzymes were normal. Months later, she developed characteristic skin lesions, leading to the diagnosis of anti-MDA-5 dermatomyositis. This case emphasizes the need to recognize key skin lesions, such as ulcers, palmar, and kissing papules while maintaining a broad differential to identify atypical presentations such as pancreatitis, which can aid in the timely diagnosis and management of anti-MDA-5 dermatomyositis.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000001621

Authors: Eaman Alhassan, Katherine Ruddy, Stratos Christianakis, Leanna Wise

Institutions: University of Southern California, University of Pittsburgh, University of Pittsburgh Medical Center

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407603293

FWCI:

Cites: 7

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Related to: 10