Rapid Resolution of Perianal Crohn's Disease with Upadacitinib
Year: 2025
Type: article
Study design: Case Report
Abstract: A 20-year-old woman with ileocolonic, stricturing, and penetrating Crohn's disease (CD) presented with new onset perianal and vulvar CD despite having a diverting ileostomy and medical therapy with ustekinumab. She had previous secondary nonresponse to infliximab, vedolizumab, and adalimumab. There is a paucity of data supporting the use of medical therapies for perianal CD. Upadacitinib is approved for treatment of moderate to severely active ulcerative colitis and CD. This case demonstrates successful and rapid resolution of perianal CD within weeks of initiating upadacitinib.
Source: ACG Case Reports Journal
Authors: Kristen Brennan, Poonam Beniwal-Patel
Institution: Medical College of Wisconsin
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4407603305