Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Biliary atresia (BA) is a neonatal cholestasis disease that is characterized by fibrosclerosing and inflammato-ry obliteration of the biliary tracts, which leads to progressive liver damage. It is the most common cause of cholestasis in the first 3 months of life presented by progressive conjugated jaundice, pale acholic stools and dark with later ones being, as-cites, portal hypertension and splenomegaly. The recommend-ed treatment is kasai portoenterostomy & liver transplantation. Characterization of gut klebsiella profile in infants with biliary atresia can provide valuable information and potential disease biomarkers. Aim of Study: Our study aims to characterize the gut Kleb-siellain infants with biliary atresia. Material and Methods: This study was a case control study that included 10 infants diagnosed as BA&10 age-matched healthy infants as a control group. Results: Increase level of Klebsiellain BA group more than control group. There was significant difference between BA group & control group (p-value >0.05). Conclusion: Increased level of gut Klebsiella is associated with the incidence of biliary atresia.
Institution: Menoufia University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4407603400