Work

How to use mTOR inhibitors in children

Year: 2025

Type: article

Abstract: Paediatricians across many specialities and pharmacists are increasingly being asked to prescribe, or jointly look after, children treated with mammalian target of rapamycin (mTOR) inhibitors (eg, sirolimus and everolimus). There is an expanding list of conditions including tuberous sclerosis and vascular malformations where treatment with mTOR inhibitors may help. This brief practice pointer summarises the practical steps before starting these treatments, what potential side effects to discuss with families and what monitoring arrangements should be put in place.

Source: Archives of Disease in Childhood Education & Practice

DOI: 10.1136/archdischild-2024-327852

Authors: Yincent Tse, Nicola Vasey, Rhys Thomas, Suzy Leech, Stephen Owens, John Sayer

Institutions: Great North Children's Hospital, Newcastle University, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne Hospital, Royal Victoria Infirmary, NIHR Newcastle Biomedical Research Centre

Language: English

Topic: Tuberous Sclerosis Complex Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4407606780

FWCI: 1.066

Cites: 20

Cited by: 2

Related to: 10