Work

Spray freeze-drying for inhalable L-leucine, mannitol-based microparticles: The impact of process variables, L-leucine, and crystallinity on Aerosolization properties

Year: 2025

Type: article

Abstract: In this study, microparticles carrying salbutamol sulphate were produced by pneumatic spray freeze-drying. The optimal particle size was assessed through a model, associated with a design of experiments. Growing solid concentrations and N 2 flow rate led to decreasing geometric diameters, while an opposite effect was associated with the feed flow rate. The aerodynamic diameter, instead, increased at increasing solid concentrations. Moreover, the role of crystallinity in determining the microparticles' flowability was evaluated upon the incorporation of L-leucine. The addition of the amino acid induced the formation of two morphologies with different degrees of crystallinity. The absence of recrystallization significantly improved the aerosolization properties of the microparticles up to a maximum fine particle fraction (48 %) and a minimum mass median aerodynamic diameter (2 μm) at 10 % ( w/w db) L-leucine. This result disclosed the influence of polymorphism on the microparticles' cohesiveness, proving the dependency of the microparticles' aerodynamics on L-leucine and mannitol crystallinity.

Source: Powder Technology

DOI: 10.1016/j.powtec.2025.120788

Authors: Lorena Pasero, Adamo Sulpizi, Tomaso Guidi, Roberto Pisano

Institutions: Politecnico di Torino, Chiesi (Italy)

Language: English

Topic: Inhalation and Respiratory Drug Delivery

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $4,610

Funders: Chiesi Farmaceutici, Ministero dell'Università e della Ricerca