Work

Taraxacum coreanum Inhibits Agonist-Induced Platelet Aggregation Without Affecting Blood Coagulation

Year: 2025

Type: article

Abstract: Taraxacum coreanum Nakai (T. coreanum) is a traditional Korean plant widely consumed for its health benefits, but its role in thrombosis prevention remains unclear. This study examined the inhibitory effects of T. coreanum extract (TCE) on platelet aggregation and thrombus formation. Using washed human platelets and platelet-rich plasma stimulated with collagen, thrombin, ADP, or TPA, TCE significantly inhibited platelet aggregation without cytotoxicity. Mechanistically, TCE reduced serotonin release, ATP release, calcium mobilization, P-selectin expression, integrin αIIbβ3 activation, and thromboxane A2 production. These actions involved the inhibition of cyclooxygenase-1 activity and modulation of PI3K/Akt and MAPK signaling. TCE also enhanced the cAMP pathway, increasing PKA, VASP, and IP3R1 phosphorylation, and delayed thrombin-induced clot retraction. These results suggest that TCE exerts potent anti-platelet and anti-thrombotic effects by modulating key pathways involved in platelet activation and thrombus formation. Thus, TCE may represent a promising natural therapeutic agent for preventing thrombotic diseases.

Source: Applied Sciences

DOI: 10.3390/app15042053

Authors: Gisuk Nam, Soyoung Kim, Yun-Suk Kwon, Kyung-Soo Nam

Institutions: Honam University, Dongguk University, Dongguk University WISE, National Institute of Horticultural and Herbal Science

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,896