Composite porous biopolymer multilayer films as potential controlled delivery systems for tolfenamic acid
Year: 2025
Type: conference-paper
Abstract: The aim of this paper is to investigate the potential of composite porous biopolymer films, created by lyophilization of solutions of two different biopolymers (Poly-D-lactic acid/PLA and Poly-ɛ-caprolactone/PEC) at different mass ratios (pure PLA, 3-to-1, 1-to-1, 1-to-3 and pure PEC), for controlled release of a chosen bioactive substance (tolfenamic acid). For this purpose, the prepared porous films were charged under corona discharge in a standard triode system (consisting of a charging electrode/needle supplied with 5 kV of a chosen polarity, a grid supplied with 1 kV with the same polarity as the charging electrode/needle and a grounded electrode) with positive charges. A set number of chitosan and casein multilayers were deposited on the surface of the charged porous films using a standard layer-by-layer (LbL) deposition technique, with the bioactive material being loaded in the casein layers. The drug release kinetics and the total amount of released drug in a standard dissolution medium were determined with the use of a spectrometer.
Authors: A Grigorov, A Viraneva, M Marudova, G Zsivanovits, T Yovcheva
Institutions: Plovdiv University, Agricultural Academy
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4407641818