Year: 2025
Type: article
Abstract: Hydrogenation of the semisynthetic vinca alkaloid vinpocetine produces two epimers that have previously been investigated as chiral additives. However, the absence of a full characterization generated some ambiguities in their stereochemical identification. In this study, computational methods, NMR analysis, and X‐ray crystallography were employed to clarify and revise the previously reported assignment. Additionally, various methods for the reduction of the 16,17‐double bond of vinpocetine are explored. A comparative analysis of epimer formation ratios with the corresponding alcohols is presented, supported by a detailed NMR characterization of these previously unexplored alkaloids.
Source: ChemistrySelect
Institution: University of Milan
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,880
OpenAlex ID: W4407643385