Cover Feature: Design, Synthesis, and Anti‐Prostate Cancer Potential of 2‐(4‐Nitrobenzyl) Malonates In Vitro and DAL Acute Oral Toxicity Assessment In Vivo (ChemMedChem 4/2025)
Year: 2025
Type: article
Abstract: 2-[(4-Nitrophenyl)methyl]propanedioates and 2-[(4-aminophenyl)methyl]propanedioates were synthesized with malonates and 4-nitrobenzyl bromide as starting materials. The six compounds were spectrophotometrically characterized post-purification and evaluated for their antioxidant, anti-inflammatory, and anticancer properties with a variety of assays. The most potent compound 3c was evaluated for its efficacy in vivo in a Dalton Ascites Lymphoma murine model and evaluated computationally for its apoptosis-inducing abilities. More details can be found in article 10.1002/cmdc.202400371 by Simone Carradori, Prasanna Ramani, and co-workers.
Source: ChemMedChem
Institutions: Amrita Vishwa Vidyapeetham, University of Chieti-Pescara
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4407647113