Augmented Bone Morphogenetic Protein Signaling During TMJ Development Alters Morphology in a Timepoint-Dependent Manner
Year: 2025
Type: article
Abstract: The temporomandibular joint (TMJ) is unique in both developmental origin and functional maintenance. The role of bone morphogenic protein (BMP) signaling in endochondral ossification has been widely investigated but not in the context of the TMJ. We employed a histomorphometric analysis approach to understand how augmented BMP signaling in the cranial neural crest affects the postnatal development of the TMJ. Our analysis showed that cartilage length in the mandibular condyle was reduced in Wnt1 Cre;caBmpr1a mice before the weaning stage (P17). However, following weaning, the mandibular condylar cartilage showed recovered length (P28 and P42). Furthermore, the changes in cartilage length coincide with alterations in cell death in the superficial region of the mandibular condyle. These results suggest that BMP signaling influences chondrocyte cell death and TMJ development in a timepoint-specific manner.
DOI: 10.3390/ijms26041655
Authors: Susannah C. Midla, Maiko Omi-Sugihara, Madeline Cha, Coral Chen, Rafael Correia Cavalcante, Haichun Pan, Yuji Mishina, Hiroki Ueharu
Institutions: University of Michigan, The University of Osaka
Language: English
Subfield: Complementary and Manual Therapy
Field: Health Professions
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: G1287925916, G2835489305, G3308065151, Tissue Engineering and Regeneration, G4593925425, G4599319085, 顎骨におけるメカニカルストレス応答性の骨代謝制御機構の解明, Molecular pathogenesis of craniosynostosis caused by enhanced BMP signaling, MicroCT 100, A new model for spatio-temporal coupling of bone formation and bone resorption governed by osteoclasts, G7758699899, G7854316889, Michigan Integrative Musculoskeletal Health Core Center (Overall Application)
OpenAlex ID: W4407666404