PTSD Symptoms and their Relationship with Depression, Anxiety, and Physical Health in Patients undergoing Treatment for Advanced Stage Lung Cancer
Year: 2025
Type: preprint
Study design: Observational Study
Abstract: Purpose Advanced stage lung cancer (ASLC) is a leading cause of cancer mortality. Patients undergoing treatment for ASLC often experience significant comorbid psychiatric and physical distress. Given the acutely life-threatening nature of ASLC, and distressing physical symptoms, patients may be at risk for post-traumatic stress disorder (PTSD). Methods This study investigated PTSD symptoms and their association with psychiatric comorbidities and physical health concerns among a subsample of 77 adults undergoing active treatment for ASLC as part of a cross-sectional mixed methods design. Results Approximately 14.5 percent of the sample reported clinically significant PTSD symptoms. Symptom severity was positively correlated with anxiety and depressive symptoms (p < .001), and physical concerns including pulmonary symptoms, poor sleep quality, pain intensity, and pain-related interference. Conclusions PTSD symptoms were elevated among patients with ASLC and uniquely linked to difficulties with sleep and pulmonary symptoms. Further assessment is needed as these symptoms are often accompanied by other psychiatric symptoms and physical health concerns that can erode well-being and quality of life.
Source: Research Square
Authors: Christopher Penn, James Gerhart, Shriya Saxena, Laurie McLouth
Institutions: University of Kentucky, Ohio University
Language: English
Topic: Cancer survivorship and care
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4407668140