Characteristics and antimicrobial susceptibility of bacteria causing acute otitis media in children at Vietnam National Children’s Hospital: a cross-sectional study
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background Acute otitis media (AOM) is a leading cause of healthcare visits, antibiotic prescription and complications in children aged under 5 years. Following the introduction of pneumococcal conjugate vaccines (PCVs), non-typeable Haemophilus influenzae (NTHi) has become the most common causative agent for AOM, followed by Streptococcus pneumoniae and Moraxella catarrhalis. PCVs are not yet included in the National Immunization Program in Vietnam. Objectives To determine the frequency and characteristics of the pathogens related to AOM in Vietnam in children ≤5 years old. Methods This was a cross-sectional study performed at the Vietnam National Children’s Hospital from October 2021 to December 2023 in children ≤5 years old diagnosed with acute suppurative otitis media. Clinical features of the children were described. Pathogens of interest were identified by culture or real-time PCR (rtPCR). The antibiotic susceptibility profiles of H. influenzae and S. pneumoniae isolates were determined. Results In total, 482 children ≤5 years old were included, of which 70.8% were ≤2 years old and 61% had an history of AOM. The most frequent bacteria isolated were H. influenzae (52.1%, 99.6% of which were NTHi) and S. pneumoniae (41.1%). Most S. pneumoniae isolates were resistant to azithromycin, clarithromycin and cefuroxime. Most H. influenzae isolates were resistant to amoxicillin, cefixime, cefuroxime, azithromycin and clarithromycin. Conclusions The pathogens most frequently associated with AOM in this study were in line with previous findings. Many isolates were resistant to commonly given oral antibiotics. These results can inform decision-making on AOM prevention and treatment strategies in Vietnam.
Source: JAC-Antimicrobial Resistance
Authors: Hồng Điệp Đỗ, Minh Điển Trần, Tuyết Xương Nguyễn, Thị Bích Thủy Phùng, Thị Bích Ngọc Hoàng, Thị Lan Liên Phạm, Minh Nguyen, Elena DeAngelis, Hữu Tiệp Thân, Khắc Trưởng Nguyễn, Adriana Guzman-Holst
Language: English
Topic: Ear Surgery and Otitis Media
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,781
Funder: GlaxoSmithKline Biologicals
OpenAlex ID: W4407675992