New Peripheral Pyridine‐Substituted Cobalt, Copper, and Manganese Phthalocyanines as Potential In Vitro Acetyl/Butyrylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease
Year: 2025
Type: article
Abstract: ABSTRACT In this research, we designed phthalocyanine compounds that are thought to be used as potential acetyl/butyrylcholinesterase inhibitors in the treatment of Alzheimer's disease. First, phthalonitrile compound (PNM‐CN), which is the precursor compound for phthalocyanines, was synthesized. Then, by cyclotetramerizing this compound, pyridine‐substituted peripheral cobalt (PNM‐CoPc), copper (PNM‐CuPc), and manganese (PNM‐MnClPc) phthalocyanine compounds were synthesized, and their structures were described using mass, NMR (except phthalocyanines), FT‐IR, and UV–Vis (except phthalonitrile) spectroscopic techniques. Investigations were carried out into the new pyridine‐substituted peripheral (PNM‐Cu/Co/MnClPcs) phthalocyanines' in vitro inhibitory properties against butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE). With an IC50 of 5.95 ± 2.12 μM (AChE) and 0.74 ± 0.01 μM (BuChE), PNM‐CuPc showed the most potent inhibitory effect against AChE and BuChE among all compounds.
Source: Applied Organometallic Chemistry
DOI: 10.1002/aoc.70045
Institution: Karadeniz Technical University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,430
OpenAlex ID: W4407682663