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Cisplatin-Induced Renal Salt Wasting in a Patient With Mediastinal Nonseminomatous Germ Cell Tumor

Year: 2025

Type: article

Abstract: Cisplatin is a platinum-based, effective chemotherapy agent that is limited by nephrotoxicity. Hyponatremia is a common concern and both renal salt wasting (RSW) and SIADH can occur. The challenge lies in the diagnostic differentiation of RSW and SIADH, since the treatment of the two conditions differs. We present a 25-year-old man with a mediastinal nonseminomatous germ cell tumor undergoing VIP chemotherapy (etoposide, cisplatin, and ifosfamide), who developed polyuria and electrolyte imbalances indicative of RSW and Fanconi-like syndrome. This case underscores the importance of early diagnosis and tailored management of cisplatin-induced RSW to prevent severe renal impairment.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2024.0862

Authors: Paavana Varanasi, Musab S. Hommos, Bhavna Bhasin-Chhabra

Institution: Mayo Clinic in Arizona

Language: English

Topic: Electrolyte and hormonal disorders

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407686396

FWCI:

Cites: 15

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Related to: 10