Work

Life-threatening fentanyl overdose beyond medullary depression in breathing

Year: 2025

Type: article

Abstract: Fentanyl overdose induces an instant decrease in arterial transport of O 2 , with a very early drop in cardiac output, out of proportion of O 2 requirement. These results point to the prominent role of the cardiac (through bradycardia) and circulatory effects of fentanyl as major contributors to the lethality of a fentanyl overdose when apnea and hypoventilation-induced hypoxemia develop.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00238.2024

Authors: Annick Judenherc-Haouzi, Tristan Lewis, Amanda Reinhardt, Philippe Haouzi

Institutions: Cleveland Clinic, Case Western Reserve University

Language: English

Topic: Opioid Use Disorder Treatment

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute