Engineered Nanocatalyst‐Enabled Cheolesterol Depletion for Enhanced Tumor Piezocatalytic Therapy
Year: 2025
Type: article
Abstract: The inadequate generation of reactive oxygen species (ROS) and metastasis of malignant tumors are critical factors that limit the efficacy of conventional sonodynamic therapy in cancer treatment. Herein, an engineered piezocatalyst: cholesterol oxidase (CHO)‐loaded Pt‐ZnO nanoparticles (Pt‐ZnO/CHO) that can explosively generate large amounts of ROS and block the metastasis of tumor, is developed for improving piezocatalytic tumor therapy. In this process, Pt‐ZnO can substantially generate ROS via initiating ultrasound (US)‐triggered piezocatalytic reactions. In situ‐grown Pt nanoparticles not only optimize piezocatalytic activities but also facilitate oxygen (O 2 ) production, thereby synergistically boosting ROS generation. Moreover, O 2 produced by Pt‐ZnO can accelerate the depletion of excess cholesterol in tumor cells under CHO catalysis to disrupt the integrity of lipid rafts and inhibit the formation of lamellipodia, significantly suppressing the proliferation and metastasis of tumor cells. This strategy by promoting ROS generation and blocking the metastatic pathway of cancer cells offers a new idea for enhanced efficacy‐oriented cancer therapeutic strategies.
Source: Advanced Science
Institutions: Nantong University, Affiliated Hospital of Nantong University, Nanjing Medical University, Jiangsu University, Affiliated Hospital of Jiangsu University, University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $6,730
Awards: G135421648, G4225524015
OpenAlex ID: W4407689300