A nomogram for predicting T315I-free survival in chronic phase chronic myeloid leukemia patients: a multicenter retrospective study
Year: 2025
Type: article
Study design: Observational Study
Abstract: The T315I mutation poses a significant threat to patients with chronic phase chronic myeloid leukemia (CP-CML). This study aimed to establish a nomogram to predict the risk of T315I mutation in CP-CML patients. The training cohort included 1,466 patients from 24 hematology centers, and the validation cohort included 820 patients from an additional 20 centers. Peripheral blood blast (PBB), additional chromosomal abnormality (ACA), dasatinib use, non-EMR at 3 months, and BCR::ABLIS > 1% at 6 months were identified as independent risk factors through multivariate Cox regression analysis. The performance of the nomogram was assessed via receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). The area under the ROC curve (AUC) values at 5, 10, and 15 years were 0.874, 0.925, and 0.930 for the training cohort, and 0.864, 0.814, and 0.803 for the validation cohort, respectively. The calibration curves for both cohorts were close to the ideal diagonal, and the decision curves indicated clinical net benefit. In conclusion, we developed a nomogram to predict the 5-year, 10-year, and 15-year T315I-free survival probabilities of CP-CML patients. This tool can aid clinicians in the early prediction and timely management of high-risk CP-CML patients with the T315I mutation.
Source: Scientific Reports
Authors: Shi-wei Hu, Xiu-di Yang, Di-jiong Wu, Yi Wang, Xiao-qiong Zhu, Wei-ying Feng, Hong-lan Qian, Ying Lu, Li-li Chen, Li-hong Cao, Jing Le, Li Zhang, Yan-ping Shao, Li-rong Liu, Guo-yan Tian, Hui Zhou, Yu Chen, Xiu-feng Yin, Xiao-ning Feng, Li Huang, Kai-feng Zhang, Yong-ming Xia, Lin-juan Xu, Hui-qi Zhang, Gang Zhang, Yong-qing Jia, Xiu-jie Zhou, Gong-qiang Wu, Jin-ming Tu, Feng Zhu, Yue-feng Zhang, Guo-li Yao, Jing-jing Zhu, Hong-yan Tong, Jie Jin, Jian Huang
Institutions: First Affiliated Hospital Zhejiang University, Zhejiang Chinese Medical University, Ningbo University, Ningbo University Affiliated Hospital, Ningbo First Hospital, Zhejiang University, Shaoxing People's Hospital, First Affiliated Hospital of Wenzhou Medical University, Taizhou First People's Hospital, Zhejiang Shuren University, Ningbo Medical Center Lihuili Hospital, Wenzhou Medical University, Zhejiang Taizhou Hospital, Affiliated Hospital of Hangzhou Normal University, Sir Run Run Shaw Hospital, Lishui City People's Hospital, Quzhou City People's Hospital, Jiaxing University, First Hospital of Jiaxing, Dongyang People's Hospital, Zhoushan Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funder: Zhejiang Medical Association
OpenAlex ID: W4407692864