Do we know more about the mechanobiology of the intervertebral disc in space than on Earth?
Year: 2025
Type: article
Abstract: This work provides a perspective on the loading protocols used in whole-organ interverterbal disc culture studies using bioreactors. We put this in the context of in vivo spinal loading, and we put forward the case that the majority of previous bioreactor studies have more in common with spinal loading in space than on Earth. Finally, we provide an outlook for the future of bioreactor research, to provide data more relevant to spinal loading on Earth, and maximize the translational potential of findings to the clinical setting.
Source: JOR Spine
DOI: 10.1002/jsp2.70024
Institution: University of Exeter
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,480
Awards: G2320097784, G2982561134, A mechanobiochemical investigation into intervertebral disc health - A multidisciplinary approach using in-vivo, in-vitro, and in-silico methods, DTP 2020-2021 University of Exeter, The development and implementation of a six-axis bioreactor for regenerative therapies of the intervertebral disc, G8871732673
OpenAlex ID: W4407703187