Work

Modulating metal-organic frameworks by surface engineering of stearic acid modification for follicular drug delivery and enhanced hair growth promotion

Year: 2025

Type: article

Abstract: Cyclodextrin metal-organic frameworks (CD-MOF) as delivery carriers have gained great attention in the biomedical field. However, limited by challenges of moisture-sensitive nature, the design and application of CD-MOF-based hair follicle delivery for androgenic alopecia (AGA) has rarely been explored. We developed the metal-organic frameworks as hair follicle-targeted delivery system (SA-MOF), stearic acid (SA) was used to modify metal-organic frameworks to form a protective hydrophobic layer on the surface and provide the additional hair growth-promoting effect. Cardamonin (CAR), a newly discovered biosafety natural product, was encapsulated in SA-MOF (CAR@SA-MOF) to promote the therapeutic efficacy on AGA. CD-MOF surface-engineered nanoparticles modified by SA avoided the rapid hydration and disintegration of CD-MOF in water, which improved the drug release and follicular deposition of drug. Assisted by the delivery of SA-modified CD-MOF carriers, the drug significantly promoted cell proliferation and migration, achieving the promoting effect on hair follicle differentiation and hair regeneration in testosterone-challenged C57BL/6 mice. Simultaneously, SA modification provided additional promoting effects on human dermal papilla cell proliferation, regulating effect on keratinocyte growth factor, and activating effect of key signaling pathways. The surface engineering design of CD-MOF hair follicle drug delivery based on SA modification exhibits significant potential for the treatment of hair follicle and sebaceous gland-related diseases. Cyclodextrin metal-organic frameworks (CD-MOF) surface-engineered nanoparticles (CAR@SA-MOF) modified by stearic acid (SA) exhibited a promotion effect on hair growth and could be used as a new therapeutic strategy for androgenetic alopecia. SA-modification avoids the rapid hydration and disintegration of CD-MOF in water, which provides a new strategy for the sustained long-acting release of drugs in the skin and hair follicles. SA-modified cyclodextrin metal-organic frameworks could increase hair follicle delivery and accumulation under the ratchet effect. The therapeutic mechanisms of CAR@SA-MOF on androgenetic alopecia involve regulation of growth factors and activation of Wnt/β-catenin, AKT/ERK, and SHH/Gli signaling pathways. SA-modification provided additional promoting effect on human dermal papilla cell proliferation, regulating effect on keratinocyte growth factor, and activating effect of key signaling pathways.

Source: Journal of Nanobiotechnology

DOI: 10.1186/s12951-025-03234-z

Authors: Zehui He, Zhenda Liu, Yongtai Zhang, Teng Guo, Nianping Feng

Institutions: Zhengzhou University, Shanghai University of Traditional Chinese Medicine

Language: English

Topic: Hair Growth and Disorders

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,790