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Known laboratory abnormalities and potential targets for the conservative treatment of avascular osteonecrosis

Year: 2025

Type: article

Abstract: Avascular osteonecrosis (AON) is a common condition that most often affects people of working age (20–60 years). The disease leads to rapid destruction and collapse of the subchondral bone with subsequent development of secondary osteoarthritis of the affected joint. The current data on laboratory abnormalities in AON are presented. Biomarkers directly related to the development and progression of AON are described in detail. Ideas for future research are formulated to improve the detection and treatment of the disease.

Source: Modern Rheumatology Journal

DOI: 10.14412/1996-7012-2025-1-83-90

Authors: V. E. Bialik, M. A. Makarov, E. I. Bialik, S. A. Makarov, A. E. Karateev, A. M. Lila, V. A. Nesterenko, A. A. Bialik, D. V. Kapitonov, A. I. Gorelova

Institutions: Association of Rheumatologists of Russia, Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation

Language: English

Topic: Bone and Joint Diseases

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407717018

FWCI:

Cites: 55

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Related to: 10