Work

IgG4-related para-testicular fibrous pseudotumor- A rare benign testicular mass mimicking malignancy: A case report and literature review

Year: 2025

Type: article

Abstract: Para-testicular fibrous pseudotumors (PFP) are rare benign reactive lesions comprising of 6 % of para-testicular masses. Often misdiagnosed as malignant due to clinical and radiological overlap, they are frequently treated with aggressive surgery. We report a case of a 70-year-old male with a left inguinal swelling diagnosed post-orchidectomy as PFP. Histopathology revealed collagen-rich fibrotic tissue with lymphoplasmacytic infiltrates and IgG4-positive plasma cells. While PFP treatment requires surgical resection, testicle-sparing procedures with intraoperative frozen section assessment may prevent unnecessary orchidectomy. Further studies are needed to establish diagnostic protocols and explore the association between PFP and IgG4-related diseases. Highlights • PFPs mimic malignancy and cannot be reliably differentiated using ultrasound or MRI. • Studies suggest it to be among the spectrum of IgG-4 related disorders. • Radical orchidectomy is often performed as a result of uncertain diagnosis. • Frozen section assessment can help in avoiding unnecessary orchidectomies.

Source: Urology Case Reports

DOI: 10.1016/j.eucr.2025.102989

Authors: Yathwin Kanagavel, D. Rajiv Raj, Vittalraj Pavithra, S. Sanjanika, K. Balaji Singh

Institution: Sri Ramachandra Institute of Higher Education and Research

Language: English