Work

Advancing age and sex modulate antidyskinetic efficacy of striatal CaV1.3 gene therapy in a rat model of Parkinson’s disease

Year: 2025

Type: article

Abstract: 1.3-targeted gene therapy, highlighting the importance of including clinically relevant age and sex populations in PD studies.

Source: Neurobiology of Aging

DOI: 10.1016/j.neurobiolaging.2025.02.003

Authors: Margaret E. Caulfield, Molly J. Vander Werp, Jennifer A. Stancati, Timothy J. Collier, Caryl E. Sortwell, Ivette M. Sandoval, Jeffrey H. Kordower, Fredric P. Manfredsson, Kathy Steece-Collier

Institutions: Michigan State University, Barrow Neurological Institute, Arizona State University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: Parkinson's Disease Foundation, Syracuse University, Parkinsonfonden, National Institute of Neurological Disorders and Stroke

Awards: Striatal CaV1.3 Calcium Channels: An Overlooked Antidyskinetic Target for PD, G327957309, G3519824489, G6992832666, Genetic Silencing of Striatal CaV1.3 Calcium Channels as a Potent Antidyskinetic Therapy for PD

OpenAlex ID: W4407731186

FWCI: 2.179

Cites: 96

Cited by: 4

Related to: 10