Work

Product and trial design considerations on the path towards a vaccine to combat opioid overdose

Year: 2025

Type: article

Abstract: Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials.

Source: npj Vaccines

DOI: 10.1038/s41541-025-01083-3

Authors: Asimenia Angelidou, Jacob A. Koster, Amy C. Sherman, Caitlyn McLoughlin, Pooja Lalwani, Aisling Kelly, Ahsan Saeed, Kerry McEnaney, Lindsey R. Baden, Melissa Brogna, Elissa R. Weitzman, Sharon Levy, David J. Dowling, Ofer Levy

Institutions: Boston Children's Hospital, Beth Israel Deaconess Medical Center, Harvard University, Brigham and Women's Hospital, Broad Institute

Language: English

Topic: Opioid Use Disorder Treatment

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: G120936099, G2300673172, G3353687722, G6308296612, G7260664469, G9000255181

OpenAlex ID: W4407732818

FWCI: 5.75

Cites: 63

Cited by: 7

Related to: 10