Year: 2024
Type: article
Abstract: Epilepsy represents a significant health concern, affecting an estimated 2 million individuals in Mexico, with patients enduring more than 70 seizures daily. In the present study, refractory epilepsy was induced in Wistar rats by repeated stimulation with pentylenetetrazol (PTZ), ranging from one to one hundred stimulations. Hippocampal tissue was analyzed via scanning electron microscopy (SEM) and energy-dispersive X-ray fluorescence (EDS). The formation of solid calcium carbonate (CaCO3) crystals within the epileptic focus where observed. Notably, the concentration of CaCO3 exhibited a direct correlation with the number of stimulations, suggesting a progressive increase over the course of these events. This study puts forth a hypothesis elucidating the mechanism behind CaCO3 crystal formation in response to PTZ-induced seizures. Further research is needed to ascertain whether there exists a correlation between the dysregulation of calcium ions (Ca2+) in epilepsy and the formation of CaCO3. This inquiry opens avenues for deeper understanding and potential advancements in the diagnosis of epilepsy and related neurological disorders.
Authors: Tessy López-Goerne, Rafael Valiente, Emilio Chávez, Antonella González-Bondani, Joaquín Manjarrez, Francisco Javier Padilla-Godínez
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407740766