Work

Application Value of Novel Inflammatory Indicators in Response to Ursodeoxycholic Acid Therapy in Patients with Primary Biliary Cholangitis

Year: 2025

Type: article

Abstract: Objective: To analyze the application value of novel inflammation indicators such as the lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with primary biliary cholangitis (PBC) undergoing ursodeoxycholic acid (UDCA) treatment. We plan to further seek simple and convenient methods to assess the response of patients to UDCA treatment. Methods: We recorded routine blood tests, liver function, and vitamin D (VD) levels of PBC patients and healthy controls visiting the hospital between October 2022 and October 2023. LMR, NLR, and PLR were calculated, and differences between the two groups were analyzed. PBC patients were divided into good response and poor response groups according to the Paris I criteria, and differences in laboratory tests between the two groups were analyzed. The predictive value of novel inflammation indicators in UDCA treatment response was further analyzed using ROC analysis. Results: LMR and VD levels were significantly lower in the PBC group compared to the control group ( P =0.000, P =0.000). In PBC patients, the good response group had higher LMR than the poor response group ( P =0.001) and lower NLR than the poor response group ( P =0.015). The areas under the ROC curve for LMR and NLR were 0.682± 0.049 and 0.630± 0.052, respectively. There was a significant negative correlation between PLR and VD in PBC patients ( r =− 0.252, P =0.005). Conclusion: Low LMR and high NLR may indicate poor treatment response. And PLR also have certain predictive values for treatment response. Keywords: primary biliary cholangitis, lymphocyte/monocyte ratio, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, vitamin D

Source: International Journal of General Medicine

DOI: 10.2147/ijgm.s493132

Authors: Siqi Liu, Yongli Pang, Xiaoxi Wang, Ruihang Lin, Siqing Tunala

Institution: Inner Mongolia Medical University

Language: English

Topic: Liver Diseases and Immunity

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836