Work

Fecal microbiota transplantation in a patient hospitalized in the intensive care unit – Case report

Year: 2025

Type: article

Abstract: Clostridioides difficile infections are difficult and serious problem occurring in patients staying in intensive care units. In recent years, the number and severity of these infections, as well as the mortality rate, have been increasing, posing a serious epidemiological problem. This is caused, among other factors, by stressors, artificial nutrition, and sepsis, which lead to disturbances in the patients' microbiome. Basic method of treatment is antibiotic therapy, however some patients experience recurrences of the infection. Fecal Microbiota Transplantation (FMT) is one of the alternative methods used in treating recurring infections of Clostridioides difficile etiology (Clostridioides Difficile Infection, CDI). The presented case refers to a patient with severe pseudomembranous enterocolitis who underwent FMT twice. This report highlights the role of FMT in the treatment of severe Clostridioides difficile infections in critically ill patients.

Source: Heliyon

DOI: 10.1016/j.heliyon.2025.e42793

Authors: Katarzyna Oliwa-Libumska, Aleksandra Jaworska-Czerwinska, Malgorzata Mallek-Grabowska, Robert Wlodarski, Przemyslaw Zuratynski, Bartosz Kozlowski

Institutions: Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz University of Science and Technology

Language: English

Topic: Clostridium difficile and Clostridium perfringens research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,270