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Lymphoepithelial Carcinoma of the Lung Initially Misdiagnosed as an Intrapulmonary Lymph Node in a Frozen Section: A Case Report

Year: 2025

Type: article

Abstract: We report a case of lymphoepithelial carcinoma of the lung (LCL) in a 67-year-old male, which presented as a solitary lesion in the left upper lung, measuring 0.7 cm in diameter. LCL is a rare tumor characterized by a dense lymphocytic infiltrate, often complicating its diagnosis. The patient was initially misdiagnosed as having an intrapulmonary lymph node on the frozen section. However, further immunohistochemical (IHC) staining enabled the pathologist to correctly diagnose LCL. The patient underwent wedge resection and was diagnosed with early-stage I disease (T1N0Mx). There has been no recurrence of the disease one year postoperatively. Clinical, histopathologic, and IHC findings are described to underscore the need for heightened awareness to prevent the misdiagnosis of this condition.

Source: Cureus

DOI: 10.7759/cureus.79263

Authors: Pin-Hao Huang, Yi-Ju Lee, Jeng-Dong Hsu, Yu-Ting Yu

Institutions: Chung Shan Medical University Hospital, Chung Shan Medical University

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407755851