Integrated Seroprevalence and Genome‐Based Study of SARS‐CoV‐2 Viral Strains in N′Djamena: Insights Into Chad's COVID‐19 Epicenter
Year: 2025
Type: article
Study design: Observational Study
Abstract: The COVID-19 epidemic has shown regional variations in transmission and outcomes. As a primary hotspot in Chad, N'Djamena is crucial for comprehensive epidemiological investigation. Our study employed two methodologies: seroprevalence data collection and whole-genome sequencing of SARS-CoV-2 strains. This dual approach assessed population exposure and virus genetic diversity. Seroprevalence data indicated broader exposure than confirmed cases suggested, and genome sequencing identified multiple strains, including globally recognized variants of concern. Integrating these data provided insights into transmission dynamics, potential herd immunity thresholds, and the impact of specific variants on disease progression. Our findings underscore the importance of integrated, multidisciplinary research in infectious disease epidemiology and inform targeted public health strategies, including social measures and vaccination, to combat infectious diseases in N'Djamena.
Source: Journal of Medical Virology
DOI: 10.1002/jmv.70234
Authors: Mathiew Hota, Andrillene L. D. Wondeu, Mahamat F. Abakar, Koutaya Dezoumbe, Fatima Abdelrazakh, Sabrina Atturo, Nathan Naïbeï, Giulia Cappelli, Franck Mennechet, Fissou H. Yandai, Djamal H. Abdallah, Zongo R. F. Edgard, Abdoulaye Boukar, Choroma A. Moussa, Issa M. Yaya, Mahamat I. Hamad, Nontegyol Armand, Netalar Honorine, Kayanlengar Frederic, Adam A. Moustapha, Yanda M. Daniel, Adam M. Alim, Mahamat Grene, Oumaima Djarma, Noubaramadji Y. Suitombaye, Amine Akouya, Ouchemi Choua, Guy R. T. Dzomo, Djallaye Djimtoïbaye, Vittorio Colizzi, Mahamat A. Moussa, Marta Giovanetti
Institutions: University of N'Djamena, National Research Council, Institute for Biological Systems, Inserm, Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections, University of Rome Tor Vergata, Centre International De Reference Chantal Biya, Università Campus Bio-Medico, Fundação Oswaldo Cruz
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,730
OpenAlex ID: W4407756025