Work

Iodine‐Catalyzed Tandem Cyclization for Efficient Synthesis of Quinazolinones from Indoles and Amines

Year: 2025

Type: article

Abstract: In this study, we report an iodine‐catalyzed multicomponent reaction of indoles, glyoxylic acid or DMSO, and aliphatic amines to synthesize quinazolinone derivatives via oxygenation cleavage of the C=C double bonds of indoles. This method features mild conditions, high efficiency, and excellent functional group tolerance. The practicality of this approach is demonstrated through its application in synthesizing rutaecarpine and a scalable protocol for efficient quinazolinone production.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202401323

Authors: Rui‐Li Zhang, Xiao‐Ying Liu, Zong‐Ze Long, Kai‐Yuan Zhang, Xiang‐Long Chu

Institutions: Xinjiang Normal University, Linyi University

Language: English

Topic: Quinazolinone synthesis and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4407758692

FWCI: 1.788

Cites: 59

Cited by: 6

Related to: 10