Work

Stereoselective Synthesis of (R)-all-trans-13,14-Dihydroretinol and -Retinoic Acid

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Vitamin A (or all- trans -retinol) metabolites are involved in a wide range of cellular processes. However, the investigation of their biological role is hampered due to their very limited availability. Herein we report a stereoselective total synthesis of the vitamin A metabolites ( R )-all- trans -13,14-dihydroretinol and -retinoic acid, applying an E -selective HWE olefination and a Ru(II) catalyzed intramolecular 7- endo - dig hydrosilylation as the key steps.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.4c03173

Authors: Paul Wienecke, Adriaan J. Minnaard

Institution: University of Groningen

Language: Russian

Topic: Retinoids in leukemia and cellular processes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500