Year: 2025
Type: article
Abstract: In order to achieve the desired effect in vivo , drugs taken orally must first be dissolved in the gastrointestinal tract. With the majority of the commercially available drugs having acidic and/or basic groups, ionization and intestinal buffering are important factors underlying adequate dissolution and, accordingly, bioavailability. The aim of this work was therefore to develop a dissolution model that properly takes these factors into account when dealing with the intestinal bicarbonate buffer. Based on the assumptions that, during dissolution, steady state is reached instantaneously, all the reactions are at equilibrium save for the interconversion between H 2 CO 3 and CO 2 , and diffusion of the reactants occurs over a boundary layer of a defined thickness h , a system of differential algebraic equations was developed and solved numerically using Wolfram Mathematica. The model provided very good predictions for flux values obtained from different literature sources, while involving less simplifying assumptions compared to previous models, thus enhancing its accuracy and making it a proper and promising approach for simulating dissolution in intestinal media.
Authors: Jozef Al-Gousous, Adrin Jalali Sohi, Niloufar Salehi, Gordon L. Amidon, Peter Langguth
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,620
OpenAlex ID: W4407764629