Understanding the Gut-Brain Connection: Exploring Its Impact on Neurological Health, Neurodegenerative Diseases, and Depression
Year: 2025
Type: article
Abstract: Introduction: The microbiota gut-brain axis or the (MGBA) that incorporates gut microbiota (GM) is known to control the defensive system of our body along with the well-being of the central nervous system (CNS). The GM represents parasitic microorganisms that if in abnormal ratios throughout the body, may result in exposure to diseases, for example, Alzheimer’s and Parkinson’s. This research aims to clarify the molecular pathways through which GM dysbiosis impacts neurological health and will explore the effectiveness of probiotics and Synbiotics in restoring GM balance to improve brain function. Methodology: A comprehensive literature review was conducted, analysing peer-reviewed studies on the microbiome studies, the implications of probiotics, Synbiotics, and changes in nutrition on the composition of GM and the neuroinflammatory response of an organism. Results: The data indicate that these approaches assist in the re-establishment of adequate diversity in the GM population which helps to reduce the extent of neuroinflammation, stabilize the functioning of neurotransmitter deregulation, and enhance cognitive performance. The findings indicate the critical potential of biological agents targeting gut microbiota in the treatment of some neurological conditions. Conclusion: the modulating of GM represents a new understanding and mechanisms that can help deal with issues associated with brain health and manage prevalent complications of neurodegenerative diseases while reiterating the need for microbiome balance for the optimal functioning of CNS.
Author: Akhil Krishnan Vikraman Pillai
Institution: Caucasus University
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4407765289