Work

Transcription Factors Fzc9 and Pdr802 Regulate ATP Levels and Metabolism in Cryptococcus neoformans

Year: 2025

Type: article

Abstract: Transcription factors Fzc9 and Pdr802, characterized by their Zn2Cys6 DNA-binding domain, are essential for the virulence of Cryptococcus neoformans in lung and brain infections. Notably, the in vivo roles of Fzc9 and Pdr802 in contributing to the pathogenicity of C. neoformans are not adequately reflected by the phenotypic characteristics observed in vitro. This study investigates the effects of gene deletion of FZC9 or PDR802 on the proteomic and metabolomic profiles of C. neoformans. Using mass spectrometry analysis, we identified significant changes in protein abundance and metabolite levels, particularly in pathways related to ATP synthesis. These findings deepen our understanding of the metabolic roles of Fzc9 and Pdr802, suggesting potential targets for the development of novel therapeutic strategies against C. neoformans infections.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms26051824

Authors: Yuanyuan Ma, Peng Xue

Institution: Nantong University

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499