Prevalence and concomitance of diabetic peripheral sensory neuropathy and lower limb peripheral arterial disease in type II diabetics and its correlation with obesity
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Among type 2 diabetics (T2D), macrovascular complication lower limb Peripheral Arterial Disease (PAD) and microvascular complication Diabetic Peripheral Sensory Neuropathy (DPSN) have scarcely studied concordance and their association with obesity. Qualitative and general body fat parameters give a complete picture of obesity. We studied the association of vibration perception threshold (VPT)-based DSPN and ankle brachial pressure index (ABPI))-based PAD, and the effect of obesity on them, in T2Ds. Methods: value < 0.05 as statistically significant. Results: T2Ds had a mean age of 53 years, a mean duration of 67 months, and 48% glycemic control. The prevalence of abnormal VPT and ABPI was 64% and 23%, respectively. VPT-based subgroups do not defer significantly from ABPI and vice versa. Obesity was associated with only abnormal ABPI (visceral > general). Odd's ratio for neuropathy with vasculopathy was insignificant while VPT and ABPI had differences in significant predictors. Conclusion: T2Ds having 64% neuropathy and 23% vasculopathy had one-third concomitance but lack of association and different predictors for each. Vasculopathy not neuropathy was associated with obesity; visceral more than general; suggesting scope for its rectification. It suggests different progression of these complications, despite some cross-talk between them.
Authors: Jayesh Dalpatbhai Solanki, Axat Pragnesh Shah, Nisha Lalwani, Bansi Janakbhai Trivedi, Avan Ashokbhai Savani, Krupali Parshottambhai Sojitra
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $450
OpenAlex ID: W4407773405