Work

Asymmetric Catalytic Aziridination to Synthesize Spiro‐aziridine Oxindoles

Year: 2025

Type: article

Abstract: Asymmetric catalytic aza-Michael-initiated ring closure of methyleneindolinones with N-tosyloxycarbamates has been established. The reaction using a chiral nickel complex catalyst enabled the formation of a series of spiro-aziridine oxindoles in good yields (up to 99 %) with high stereoselectivity (up to 97 % ee, >19 : 1 dr) under mild reaction conditions. Ring-opening of spiro-aziridine oxindole leads to formation of glycinate-bearing oxindoles with retention of configuration.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202500302

Authors: Yinhe Qu, Zhenzhong Liu, Yuqiao Zhou, Xiaoming Feng, Xiaohua Liu

Institution: Sichuan University

Language: English

Topic: Synthesis and Catalytic Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China

Awards: G4890951106, G5888959213