Work

Identification of GPX3 and JUN as Tumor Suppressors in Thyroid Cancer through Integrated WGCNA and Mendelian Randomization

Year: 2025

Type: article

Abstract: This study identifies GPX3 and JUN as critical tumor suppressor genes in TC, with their function closely linked to T regulatory cells and follicular helper T cells. The overexpression of GPX3 and JUN demonstrates significant tumor-suppressive activity, highlighting their potential as effective therapeutic targets in combating TC.

Source: Journal of Cancer

DOI: 10.7150/jca.104687

Authors: Renjie Zhang, Yutao Chen, Sha Xu, Xue Gu, Hui Ye

Institutions: Affiliated Hospital of Guizhou Medical University, Guiyang Medical University, Guizhou Cancer Hospital

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,337