Work

The E3 ubiquitin ligase MAEA promotes macrophage phagocytosis and inhibits gastrointestinal cancer progression by mediating PARP1 ubiquitination and degradation

Year: 2025

Type: article

Abstract: These data suggest that MAEA offers value as a prognostic biomarker and target for the treatment of GIC owing to its ability to degrade PARP1 and augment the phagocytic activity of macrophages.

Source: International Journal of Biological Sciences

DOI: 10.7150/ijbs.102796

Authors: Yanchun Feng, Xiangcai Zou, Jintuan Huang, Zhenze Huang, Guanghao Kuang, Yingming Jiang

Institutions: Zhujiang Hospital, Southern Medical University, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Sun Yat-sen University, Sixth Affiliated Hospital of Sun Yat-sen University

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,337

OpenAlex ID: W4407776676

FWCI: 1.762

Cites: 35

Cited by: 7

Related to: 10