Role of 2-hour plasma glucose in assessing pre-diabetes risk: insights from the vitamin D and type 2 diabetes (D2d) study cohort
Year: 2025
Type: article
Abstract: Historically, an elevated level of 2-hour plasma glucose (2hPG) during a 75-gram oral glucose tolerance test (OGTT) was the hallmark of pre-diabetes. This measurement served as a primary criterion in pivotal diabetes prevention clinical trials, including the Diabetes Prevention Program.1 However, with the American Diabetes Association (ADA) expanding its diagnostic criteria for pre-diabetes in 2010 to include hemoglobin A1c (HbA1c),2 clinical practice has shifted from measuring 2hPG to relying primarily on fasting plasma glucose (FPG) and HbA1c.3 This transition raises questions about the current role of 2hPG in assessing pre-diabetes risk in contemporary clinical settings.
Institutions: Stanford Medicine, Stanford University, Brigham and Women's Hospital, Harvard University, Duke University, Duke Medical Center, Kaiser Permanente Center for Health Research, Tufts Medical Center, Tufts Clinical and Translational Science Institute, VA Eastern Colorado Health Care System, University of Colorado Anschutz, National Institute of Diabetes and Digestive and Kidney Diseases, Pennington Biomedical Research Center
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,000
OpenAlex ID: W4407779413