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DBU-mediated C-C bond formation between Baylis-Hillman Acetates and Active Methylene Compounds

Year: 2025

Type: article

Abstract: A new reagent system for the formation of C-C bond between the Baylis-Hillman acetates and active methylene compounds (AMCs) were developed. This method provides tri-substituted alkenes as the major product in good yield under neat condition. The reaction proceeds through the SN2ꞌ mechanism to give substituted alkenes in good yields with high stereoselectivity. 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU) act as a unique base which accelerate the rate of the reaction.

Source: Indian Journal of Chemistry

DOI: 10.56042/ijc.v64i2.15867

Authors: Sonam Tashi Khom, Pranjit Saikia, Nagendra Nath Yadav

Institution: North Eastern Regional Institute of Science and Technology

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: University Grants Commission

OpenAlex ID: W4407783134

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