Work

Assembly of (E)‐γ‐Lactones Fused Five‐ or Six‐Membered Ring via Palladium‐Catalyzed Cascade Annulation Reaction

Year: 2025

Type: article

Abstract: A palladium-catalyzed divergent cascade annulation reaction of unactivated cycloalkenes with alkynoic acids under aerobic conditions is accomplished. This catalytic protocol provides an efficient and economical strategy to accommodate a broad scope of (E)-γ-lactones fused five- or six-membered ring motifs with good regioselectivities and yields (57 examples, up to 94 % yield and E/Z up to 98 : 2). More importantly, the developed catalytic strategy is applicable to a wide array of unactivated cycloalkenes, including cyclopentene, cyclohexa-1,3-diene, cyclohexa-1,4-diene, cyclohepta-1,3-diene and conjugated 1,3-diene.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202401701

Authors: Jianxiao Li, Yanan Niu, Dan He, Bowen Wang, Huanfeng Jiang

Institutions: Shaoguan University, Key Laboratory of Guangdong Province, South China University of Technology

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China

Awards: G1328909366, 可控的钯催化剂的制备及其催化炔烃高值化转化新方法研究