Synthesis of α-Amino phosphonates catalyzed by bifunctional cyclohexane derived thiourea organocatalyst
Year: 2025
Type: article
Abstract: Multicomponent phosphonylation is accomplished by convenient and efficient synthetic method using novel (S)-N-((cyclohexylmethyl) carbamothioyl) pyrrolidine-2-carboxamide (NCCPC) as bifunctional cyclohexane derived thiourea organocatalyst upon the reaction of an amine, substituted aldehyde with diethyl phosphite. This method not only provides novel and excellent complement for the synthesis but also gives green and transition-metal-free protocol, shows a broad substrate scope, providing a variety of α-amino phosphonates in moderate to good yield.
Source: Indian Journal of Chemistry
Authors: Dr. Hanmant Kasralikar, Dr.Shrinivas Nakkalwar
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
Funder: University of the Punjab
OpenAlex ID: W4407786321